James Darren Mathis, 37, from Huntington, WV is missing and his car was found on the 31st Street Bridge on Friday, Dec. 13.
Family members told officers they last saw Mathis about 9 p.m. on Thursday, Dec. 12, 2013. Officers add that family members did not notice Mathis was missing from the home until around 1:30 a.m. the next morning.
The Coast Guard did a search of the river but found nothing.
He is described as a white male, 145 pounds, 5 ft. -11 inches tall.
Anyone with information on Mathis or his whereabouts is asked to call the Huntington Police Department tip line at (304) 696-4444 or 911.