Police are searching for Tiffany Ortiz, 13 and Jaeden Gandia, 12, who live at 546 Putnam Avenue in Brooklyn, New York.
They were last seen leaving the home around 10 a.m. on Thursday.
Ortiz is 5′ tall and 95 pounds with brown eyes and brown hair. She was last last seen wearing blue jeans, tan boots and a pink hooded sweatshirt.
Gandia is also 5 feet tall and weighs 110 pounds. He has medium build with brown eyes and brown hair and was last seen wearing a black leather coat, blue jeans, an orange t-shirt and black sneakers.
Anyone with information on where they might be should call Crime Stoppers at 1-800-577-TIPS (8477)